3D reconstruction of biopsy series
Traditionally prostate biopsy series (for instance 12 samples taken out of the gland as regularly as possible) are executed under endorectal 2D ultrasound control. The real position of the samples is never exactly known. Based on 3D ultrasound elastic registration tools, we developed a method for accurate localization of the biopsies in a single referential. Such a representation enables precise localization of tumoral regions of the gland if any detected by anatomo-pathologists and targeted treatments. A clinical study involving more than 50 patients has demonstrated quantitatively the systematic lack of samples for some regions of the prostate and a learning curve due to the 3D representation of the biopsy sessions to the clinician. This system also enables mapping several biopsy series of a same patient performed at different times.
Reference : P.Mozer. « Urologie et GMCAO » (in french), Ph.D thesis, UJF, Juin 2007 (pdf can be downloaded from the HAL database) P. Mozer, M. Baumann, G. Chevreau, A. Moreau-Gaudry, S. Bart, R. Renard-Penna, E. Comperat, P. Conort, M.-O. Bitker, E. Chartier-Kastler, F. Richard, J. Troccaz. Mapping of Transrectal Ultrasound Prostate Biopsies: Quality Control and Learning Curve Assessment by Image Processing, Journal of Ultrasound in Medicine, 2009, 28(4):455-460 460 (pdf ) Mozer P, Chevreau G, Troccaz J, Renard-Penna R. Intérêt du guidage 3D et de la localisation des biopsies de prostate par voie endorectale. Progrès en Urologie (Cahiers de Formation Continue), 2011, 21(3) :F86-F90 (pdf)
Collaborations : Urology department of La Pitié Salpétrière Hospital (Dr Mozer) – société KOELIS
Status : FINISHED PhD thesis defended in June 2007 – Clinical evaluation in progress (more than 100 patients included) – Patent applied – Commercial product (EC marked an FDA approved) made available by KOELIS.
More information: Best thesis award 2008 SFGBM/IEEE EMBS (section France)
Contact : jocelyne.troccaz@imag.fr or pierre.mozer@psl.aphp.fr