Eric Fanchon


Contact information

e-mail:  Eric.FanchonRM@imagRM.fr    (where RM = remove this)
office: B37, bâtiment Taillefer / IN3S, Hôpital Nord  [access]
address: TIMC-IMAG Laboratory, BCM Team, Faculté de Médecine, 38041, Grenoble, France [google map]
phone: +33 4 56 52 00 27
fax:      +33 4 56 52 00 55
 


Research Interests

Development of formal methods for the dynamical modeling of biological systems, represented as interaction networks. The global objective is to assist in reasoning during the process of model building and validation. This includes: building a model from observations; representing formally partial knowledge about global behaviour; inferring possible parameter values from known behaviours; revising an inconsistent model; generating proposals for new informative experiments.
Our computational approach is based on (i) discrete dynamical systems; (ii) constraints, currently Constraint Logic Programming (CLP) and boolean satisfiability (SAT). Through collaboration with biologists, we apply the method to gene regulatory networks and signaling pathways (adhesion between endothelial cells, nutritional stress in E. coli, segmentation of the early embryo of Drosophila).
More recently we have turned to formal methods (reachability analysis, temporal logics) developed for continuous and hybrid dynamical systems. We applied them to a biochemical network involved in the degradation of the extracellular matrix (in the context of angiogenesis), and to a network involved in iron homeostasis (in the context of Acute Myeloid Leukemia).




News  (2014)



Past events

Co-organizer, with Philippe Tracqui (TIMC lab) of the 31st seminar of the French-speaking Society for Theoretical Biology/Société Francophone de Biologie Théorique (SFBT), 15-18 may 2011 in Autrans (near Grenoble).
The Proceedings of the 31st Seminar of the French-Speaking Society for Theoretical Biology are available online on Springer's site ([editorial]).

Co-organizer, with Oded Maler and Alexandre Donzé (Verimag) of  the international workshop 'Toward Systems Biology', May 30 - June 1, 2011, Grenoble.


Collaborations



Publications

Full list here.

Fabien Corblin's PhD thesis (in french): Conception et mise en oeuvre d'un outil déclaratif pour l'analyse des réseaux génétiques discrets.

Nicolas Mobilia works on a PhD thesis entitled 'A meta-environment for biological network modelling'  (co-dir with Jacques Demongeot, funded by Microsoft Lab Cambridge, UK).


Teaching



Vitae

1983: Engineering school degree (Physical Engineering, ENSIEG, Grenoble)

1983-1985: Teaching assistant in the physics department of the University of Monastir, Tunisia.

1987: PhD in solid state physics (Crystallography lab, CNRS, Grenoble).
Keywords : X-ray crystallography, one-dimensional superionic conductors, disorder, phase transitions.

1988-1990 : post-doctoral position in Wayne Hendrickson's lab, Columbia University/HHMI, Dpt of Biochemistry and Molecular Biophysics, New York, NY.
Study of the anisotropy of  the anomalous scattering of X-rays and how to take it into account when phasing protein structures with the MAD (Multiple-wavelength Anomalous Diffraction) method.

1990-2006 : CNRS position at Institut de Biologie Structurale (Grenoble), in the Macromolecular Crystallography Lab (Otto Dideberg).

Work in the team in charge of the design, building and running of 2 synchrotron beamlines at ESRF. Development of the Multiple-wavelength Anomalous Diffraction method for the determination of the 3d structure of proteins.

2007-present :  TIMC-IMAG, team BCM (Biologie Computationnelle et Mathématique / Computational and Mathematical Biology).


last modified feb 2014