Emmanuel Promayon

Home Page Publications List Sorted Internship/Stages Teaching Contact

Jump to : Download | Abstract | Keywords | Contact | BibTex reference | EndNote reference |


E. Promayon, J. -L. Martiel, P. Tracqui. Physically-Based 3D Simulations of Cellular Traction Forces, Migration and Cytokinesis of Cells Adherent to an Elastic Substratum. In SFB-Workshop on Simulations of Polymer and Cell Dynamics, Bonn, June 2000.


Download paper: Adobe portable document (pdf)

Copyright notice: Disclaimer: this material is presented to ensure timely dissemination of scholarly and technical work. Files of articles may be covered by copyright. You may browse the articles at your convenience in the same spirit as you may read a journal or conference proceedings in a public library. Retrieving, copying, distributing these files, entirely or in parts, may violate copyright protection laws. Copyright and all rights therein are retained by authors or by other copyright holders. All person copying this information are expected to adhere to the terms and constraints invoked by each author's copyright. In most cases, these works may not be reposted without the explicit permission of the copyright holder.


A suggestive approach of the cell mechanical activity can be based on simulation models considering the contractile activity of the cell cytoskeleton on one hand, the dynamic formation and breakage of cell attachments with the underlying substratum on the other hand.We have developed a physically-based interactive 3D computer model which integrates a mechanical analysis of: - the cell spreading and contraction, - the resistance of and affinity of cell-substratum adhesiveness. In our model, each structure is a part of a global object. Each part of the global object is described by a set of mass points on its contour and defined locally in terms of physical (mass, velocity) and mechanical parameters (compressibility, elasticity/rigidity).Our approach consists in uncoupling normal finite forces and constraint forces. Our method considers all kind of differentiable constraints (volume constraints, fixed or moving position constraints, {\ldots}). Particularly, the volume can be kept exactly constant during deformation without using an iterative process (as used in Lagrangian approaches).A limited number of forces is used to deform the object, the most interesting being contraction forces (modelling the cell contractile activity) shape memory forces (rendering elastic behaviour). All these forces are computed by using the attractive point concept: at each iteration, the ideal position (or speed) for a given mass point is first computed, then a spring force is modelled between the real position and the ideal position (which becomes an attractive point). Some simulation results illustrate the interest of our approach for analysing different aspect of cell deformation and locomotion)


[ Cell ] [ Softtissue ]


Emmanuel Promayon http://membres-timc.imag.fr/Emmanuel.Promayon

BibTex Reference

   Author = {Promayon, E. and -L. Martiel, J. and Tracqui, P.},
   Title = {Physically-Based 3{D} Simulations of Cellular Traction Forces, Migration and Cytokinesis of Cells Adherent to an Elastic Substratum},
   BookTitle = {SFB-Workshop on Simulations of Polymer and Cell Dynamics},
   Address = {Bonn},
   Month = {June},
   Year = {2000}

EndNote Reference [help]

Get EndNote Reference (.ref)

Home Page Publications List Sorted Internship/Stages Teaching Contact
This page was automatically generated thanks to JabRef and bib2html , 8 February 2019